HARNESSING THE EVOLUTIONARY POWER OF LACTOFERRIN

    // DESIGNED BY NATURE FOR YOUR OPTIMAL HEALTH. //

    Lactoferrin is a bioactive protein and a key ingredient in mothers' milk. It is produced naturally in your mucous membranes, gut and saliva as nature's first line of defence.

      • Anti-viral

        Lactoferrin binds to viral particles directly, blocking them from connecting to your cells. It also binds to cell surface receptors that viruses use, making it harder for the viruses to enter and infect the cells.

      • Anti-bacterial

        By binding to iron, lactoferrin deprives harmful bacteria of an essential nutrient they need to grow and multiply. Lactoferrin also weakens the bacterial cell walls, making it easier for white blood cells to recognise, target and destroy the bacteria.

      • Microbiome and gut health

        Immune health starts in the gut. Lactoferrin acts as a prebiotic in the gut, encouraging the growth of beneficial bacteria in the intestinal tract. Lactoferrin helps protect and repair the gut mucosa, making it more effective at preventing harmful pathogens from entering the body and supports the promotion of beneficial bacteria that have a protective effect.

      • Immune modulating

        Lactoferrin helps to balance and strengthen your immune system by supporting its natural defences against infections. Immune modulating factors, such as lactoferrin, help regulate the body's immune response. These factors either stimulate, or temper, immune activity depending on your body’s needs, to ensure a balanced and
        effective defensive response to outside threats. Immune modulating factors are crucial for maintaining strong immune health and preventing excessive immune reactions.

      • Adaptogenic

        Adaptogens are intelligent compounds that regulate your
        body’s cellular responses in the face of stress - either boosting or inhibiting pathways, depending on what your body needs. Lactoferrin supports your body’s ability to adapt to daily stressors and maintain equilibrium, and in doing so adaptogens are shown to increase your stress resilience, help balance your hormones, and support your mood.

      • Respiratory Tract Support

        In the upper respiratory tract, lactoferrin is found in the mucus. Its role is to prevent viral infections by binding to viruses and stopping them from attaching to and entering cells. This action, combined with its ability to boost the immune response, helps fortify and shield the respiratory tract from infections.

      • Anti-inflammatory

        Clinical studies show that lactoferrin reduces and calms inflammation but also stimulates your adaptive immune response to target pathogens.

      • SHOP IMMUNESHIELD 

      "Lactoferrin fortifies the body’s innate and adaptive immune system"

      Independently published and peer-reviewed lactoferrin research:

      There are over 10,000 published studies documenting the benefits of lactoferrin and its potential to optimise health at all stages of life. Here’s our curation of a few that stand out:

      IMMUNE HEALTH

      Lactoferrin for prevention of common viral infections (2013)

      • Study type: Review
      • Participants: -
      • Dose: -
      • Duration: -
      • Results: Beneficial effects of oral bovine lactoferrin found in common viral infections including the common cold, influenza, viral gastroenteritis, summer cold and herpes

      Read more: Study

      Lactoferrin for reduction of common cold like symptoms (2012)

      • Study type: Questionnaire
      • Participants: 398
      • Dose: 600mg daily
      • Duration: 3 months
      • Results: Significant decreases were found in the onset of cold-like symptoms and gastroenteritis symptoms in the bovine lactoferrin-consumption group compared with non-consumption group

      Read more: Study

      The clinical efficacy of bovine lactoferrin and IgF for the Common Cold (2013)

      • Study type: Double blind, randomised, placebo-controlled clinical trial
      • Participants: 126
      • Dose: 600mg daily
      • Duration: 3 months
      • Results: Significant decrease in the number of colds and cold-related symptoms in the general population when bovine lactoferrin is administered as a preventative supplement

      Read more: Study

      The biology of lactoferrin, an iron-binding protein that can help defend against viruses and bacteria (2020)

      • Study type: Literature Review
      • Participants: -
      • Dose: -
      • Duration: -
      • Results: Lactoferrin has immunological benefits, as well as having an important antibacterial and antiviral role. Because it is known to interfere with some of the receptors used by coronaviruses, it may contribute usefully to the prevention and treatment of coronavirus infections. Bovine lactoferrin may therefore be an excellent supplement to take, not only as a contribution to prevention but perhaps as a therapy in the event COVID-19 is diagnosed.

      Read more: Study

      Effects of lactoferrin on infectious diseases in Japanese summer (2020)

      • Study type: Randomised, double-blinded, placebo-controlled parallel-group comparative trial
      • Participants: 290
      • Dose: 200-600mg
      • Duration: 12 weeks
      • Results: The intake of bovine lactoferrin ameliorated infectious diseases, including summer colds, in a dose-responsive manner, showing suppressive effect of bovine lactoferrin on respiratory illnesses in adults.

      Read more: Study

      GUT HEALTH

      Bovine lactoferrin for Helicobacter pylori eradication (2006)

      • Study type: Randomised controlled trial
      • Participants: 402 (210 men, 192 women)
      • Dose: 200mg
      • Duration: 7 days
      • Results: The addition of bovine lactoferrin to the standard 1-week triple therapy for H. pylori infection significantly increased its eradication rate.

      Read more: Study

      Lactoferrin attenuates lipopolysaccharide-stimulated inflammatory responses and barrier impairment through the modulation of NF-κB/MAPK/Nrf2 pathways in IPEC-J2 cells

      • Study type: Cellular study
      • Participants: -
      • Dose: -
      • Duration: -
      • Results: LF treatment showed a remarkable reduction of cell permeability. Results suggested that lactoferrin alleviated LPS-induced cellular inflammation, maintaining cellular barrier integrity and mitigating oxidative stress.

      Read more: Study

      Study on the Therapeutic Benefit on Lactoferrin in Patients with Colorectal Cancer Receiving Chemotherapy

      • Study type: Double-blinded parallel randomised control clinical trial
      • Participants: 15 patients
      • Dose: 250mg
      • Duration: 3 months
      • Results: Daily administration of bovine lactoferrin showed a clinically beneficial effect to colorectal cancer patients with better disease prognosis

      Read more: Study

      The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria (2019)

      • Study type: Review
      • Participants: -
      • Dose: -
      • Duration: -
      • Results: The iron-binding capacity of lactoferrin confers the property of limiting the growth of gut pathogens, which requires iron to proliferate. Simultaneously, lactoferrin can also enhance the growth of gut-beneficial microorganisms such as Bifidobacterium and Lactobacillus. The immunomodulation of the intestinal immune system by lactoferrin on probiotics may provide natural and sustainable approaches to control infectious diseases by strengthening intestinal homeostasis.

      Read more: Study

      ALZHEIMER'S DISEASE & COGNITIVE FUNCTION

      A study on the effect of lactoferrin on Alzheimer's disease (2019)

      • Study type: Open-label, randomised, controlled pilot study
      • Participants: 50 (28 men and 22 women)
      • Dose: 250mg daily
      • Duration: 3 months
      • Results: Significantly improved cognitive function and possible protective mechanism of lactoferrin in Alzheimer's Disease through its ability to alleviate the AD pathological cascade and cognitive decline

      Read more: Study

      IRON DEFICIENCY & ANAEMIA

      The effectiveness of oral bovine lactoferrin compared to iron supplementation in patients with a low haemoglobin profile (2024)

      • Study type: A systematic review and meta-analysis of randomised clinical trials
      • Participants: -
      • Dose: 100–250 mg/day
      • Duration: -
      • Results: A safer option and with high compliance evidence, lactoferrin can serve as an iron replacement treatment for patients who may be experiencing adverse side effects due to iron intake.

      Read more: Study

      Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia (2022)

      Study type: A Comprehensive Review and Meta-Analysis of Clinical Trials

      • Participants: -
      • Dose: -
      • Duration: -
      • Results: The major advantages of lactoferrin compared with traditional iron supplement ferrous sulfate are gastrointestinal tolerance and fewer side effects caused by the intake of high-dose iron. The anti-inflammatory effect of lactoferrin can partially explain why it had a better iron-improving effect.

      Read more: Study

      BONE HEALTH & OSTEOPOROSIS

      The role of lactoferrin in bone remodeling: evaluation of its potential in targeted delivery and treatment of metabolic bone diseases and orthopedic conditions

      • Study type: Review
      • Participants: -
      • Dose: -
      • Duration: -
      • Results: By improving bone mineral density and reducing the risk of bone loss, Lf may help prevent fractures and other osteoporosis-related complications.

      Read more: Study

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